Q: Combined use of which two very commonly used antibiotics in ICU is known to have higher risk of acute kidney injury (AKI)?
Answer: Concomitant use of piperacillin-tazobactam (zosyn) and vancomycin has been reported to have higher incidence of AKI in comparison to other combinations.
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#nephrology
References:
1. Hammond DA, Smith MN, Li C, et al. Systematic Review and Meta-Analysis of Acute Kidney Injury Associated with Concomitant Vancomycin and Piperacillin/tazobactam. Clin Infect Dis 2016.
2. Navalkele B, Pogue JM, Karino S, et al. Risk of Acute Kidney Injury in Patients on Concomitant Vancomycin and Piperacillin-Tazobactam Compared to Those on Vancomycin and Cefepime. Clin Infect Dis 2017; 64:116.
3. Rutter WC, Cox JN, Martin CA, et al. Nephrotoxicity during Vancomycin Therapy in Combination with Piperacillin-Tazobactam or Cefepime. Antimicrob Agents Chemother 2017; 61.
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