Q: Which of the following drug may cause pseudo-lymphoma?
A) Atenolol
B) Captopril
C) Cephalosporins
D) Phenytoin
E) Hydralazine
Answer: D
Lymphadenopathy associated with hydantoin derivatives drugs is well known for almost 80 years. On biopsy, it is manifested as a benign lymphoid follicular hyperplasia. Clinically, it may present as fever, rash, lymphadenopathy, eosinophilia, and hepatitis. Usually, it gets resolved by the discontinuation of the drug but if symptoms persist, steroids may be helpful.
#pharmacology
#oncology
Reference:
Johns ME, Moscinski LC, Sokol L. Phenytoin-Associated Lymphoadenopathy Mimicking a Peripheral T-cell Lymphoma. Mediterranean Journal of Hematology and Infectious Diseases. 2010;2(2):e2010028.
A) Atenolol
B) Captopril
C) Cephalosporins
D) Phenytoin
E) Hydralazine
Answer: D
Lymphadenopathy associated with hydantoin derivatives drugs is well known for almost 80 years. On biopsy, it is manifested as a benign lymphoid follicular hyperplasia. Clinically, it may present as fever, rash, lymphadenopathy, eosinophilia, and hepatitis. Usually, it gets resolved by the discontinuation of the drug but if symptoms persist, steroids may be helpful.
#pharmacology
#oncology
Reference:
Johns ME, Moscinski LC, Sokol L. Phenytoin-Associated Lymphoadenopathy Mimicking a Peripheral T-cell Lymphoma. Mediterranean Journal of Hematology and Infectious Diseases. 2010;2(2):e2010028.
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