Diuretic induced hyponatremia

Q: Which of the diuretics tend to cause hyponatremia more?

A) Thiazide diuretics
B) Loop diuretics


Answer: A

Thiazide diuretic tends to cause hyponatremia due to their reduced diluting ability. This interferes with water excretion.This is a direct effect of reduced sodium chloride reabsorption without water in the distal tubule.

#nephrology
#lectrolytes


Reference:

Frenkel NJ, Vogt L, De Rooij SE, et al. Thiazide-induced hyponatraemia is associated with increased water intake and impaired urea-mediated water excretion at low plasma antidiuretic hormone and urine aquaporin-2. J Hypertens 2015; 33:627.