Drug-Eluting Stents and Coronary Artery Aneurysm

Q: The mean time period between the deployment of Drug-Eluting Stents (DES) and development of Coronary Artery Aneurysm (CAA) is

A) one week
B) one month
C) three months
D) six months
E) one year


Answer: E

Development of CAA after the deployment of DES is relatively an insidious process. Reported mean time to have its clinical effect is around 313 days. As expected, risk factors include DES deployment during an acute myocardial infarction (MI), deployment in an occluded vessel, longer coronary lesions requiring multiple overlapping stents, residual dissection, and underlying congenital and Kawasaki's disease-related aneurysms.

#cardiology
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References:

1. Alfonso F, Pérez-Vizcayno MJ, Ruiz M, et al. Coronary aneurysms after drug-eluting stent implantation: clinical, angiographic, and intravascular ultrasound findings. J Am Coll Cardiol 2009; 53:2053. 

2. Aoki J, Kirtane A, Leon MB, Dangas G. Coronary artery aneurysms after drug-eluting stent implantation. JACC Cardiovasc Interv 2008; 1:14.