PO Diflucan

Q: Care should be taken while converting intravenous (IV) fluconazole to oral (PO) route as it's bio-availability is extremely variable? 

A) True 
B) False 


 Answer: B 

Fluconazole is highly bio-available and IV form should be used only when a patient is unable to take oral medications, or for some reason poor gastrointestinal absorption is suspected.

Objective of above question is to understand the overuse and high cost of IV formulations in ICU. 

#pharmacology
#infectiousdiseases



Reference:

Diflucan - fda.gov 
https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/019949s051lbl.pdf