Diuretic as anti-seizure

Q: Which diuretic has shown some promise in suppressing temporal lobe epilepsy?



Answer:  Bumetanide 

Bumetanide has been used in neonatal refractory seizures with success. It is an inhibitor of Na-K-Cl cotransporter (NKCC). The human body has Two isoforms of NKCC

• NKCC1 is expressed in the brain, and 
• NKCC2 is expressed in the kidney 

It has shown the potential of use in patients with temporal lobe epilepsy. 


#neurology
#pharmacology



References:

1. S. Eftekhari, J. Mehvari Habibabadi, M. Najafi Ziarani, et al. Bumetanide reduces seizure frequency in patients with temporal lobe epilepsy Epilepsia, 54 (2013), pp. e9-12

2. Bumetanide enhances phenobarbital efficacy in a neonatal seizure model Ann Neurol, 63 (2008), pp. 222-235 

3.  K.T. Kahle, K.J. Staley The bumetanide-sensitive Na-K-2Cl cotransporter NKCC1 as a potential target of a novel mechanism-based treatment strategy for neonatal seizures Neurosurg Focus, 25 (2008), Article E22