Q: Fresh Frozen Plasma (FFP) is used to treat Angiotensin-converting enzyme (ACE) inhibitors induced angioedema because it contains? (Select One)
A) Angiotensin-converting enzyme (ACE)
B) bradykinin
Answer: A
Fresh frozen plasma contains a subsequent amount of the enzyme ACE, which degrades bradykinin and helps in resolution of angioedema. This is a common knowledge that ACE-I induced angioedema is bradykinin-mediated but very few people understand the actual reason behind using FFP in this condition. It is an effective treatment and may be very valuable during refractory or resistant ACE-I induced angioedema.
#hematology
#allergy-immunology
References:
1. Karim MY, Masood A. Fresh-frozen plasma as a treatment for life-threatening ACE-inhibitor angioedema. J Allergy Clin Immunol 2002; 109:370.
2. Warrier MR, Copilevitz CA, Dykewicz MS, Slavin RG. Fresh frozen plasma in the treatment of resistant angiotensin-converting enzyme inhibitor angioedema. Ann Allergy Asthma Immunol 2004; 92:573.
3. Hassen GW, Kalantari H, Parraga M, et al. Fresh frozen plasma for progressive and refractory angiotensin-converting enzyme inhibitor-induced angioedema. J Emerg Med 2013; 44:764.
A) Angiotensin-converting enzyme (ACE)
B) bradykinin
Answer: A
Fresh frozen plasma contains a subsequent amount of the enzyme ACE, which degrades bradykinin and helps in resolution of angioedema. This is a common knowledge that ACE-I induced angioedema is bradykinin-mediated but very few people understand the actual reason behind using FFP in this condition. It is an effective treatment and may be very valuable during refractory or resistant ACE-I induced angioedema.
#hematology
#allergy-immunology
References:
1. Karim MY, Masood A. Fresh-frozen plasma as a treatment for life-threatening ACE-inhibitor angioedema. J Allergy Clin Immunol 2002; 109:370.
2. Warrier MR, Copilevitz CA, Dykewicz MS, Slavin RG. Fresh frozen plasma in the treatment of resistant angiotensin-converting enzyme inhibitor angioedema. Ann Allergy Asthma Immunol 2004; 92:573.
3. Hassen GW, Kalantari H, Parraga M, et al. Fresh frozen plasma for progressive and refractory angiotensin-converting enzyme inhibitor-induced angioedema. J Emerg Med 2013; 44:764.
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