Q: Which of the following antibiotics can be used as an empiric single regimen in suspected acute acalculous cholecystitis?
A) Piperacillin-tazobactam
B) Cefepime
C) Ceftazidime
D) Metronidazole
E) Vancomycin
Answer: A
It is very important to cover broad-spectrum organisms appropriately for healthcare-associated intra-abdominal infections, for which acalculous cholecystitis is a prime example. Most of the time dual or triple coverage is initiated. As the focus on antibiotics stewardship is gaining momentum, appropriate single coverage should be considered. Local hospital antibiogram should be consulted. In most of the cases imipenem-cilastatin, meropenem, doripenem, and piperacillin-tazobactam are enough to cover most of the bugs. All other choices in the question require combination therapy.
#infectious-diseases
#hepatology
Reference:
1. Solomkin JS, Mazuski JE, Bradley JS, et al. Diagnosis and management of complicated intra-abdominal infection in adults and children: guidelines by the Surgical Infection Society and the Infectious Diseases Society of America. Clin Infect Dis 2010; 50:133.
A) Piperacillin-tazobactam
B) Cefepime
C) Ceftazidime
D) Metronidazole
E) Vancomycin
Answer: A
It is very important to cover broad-spectrum organisms appropriately for healthcare-associated intra-abdominal infections, for which acalculous cholecystitis is a prime example. Most of the time dual or triple coverage is initiated. As the focus on antibiotics stewardship is gaining momentum, appropriate single coverage should be considered. Local hospital antibiogram should be consulted. In most of the cases imipenem-cilastatin, meropenem, doripenem, and piperacillin-tazobactam are enough to cover most of the bugs. All other choices in the question require combination therapy.
#infectious-diseases
#hepatology
Reference:
1. Solomkin JS, Mazuski JE, Bradley JS, et al. Diagnosis and management of complicated intra-abdominal infection in adults and children: guidelines by the Surgical Infection Society and the Infectious Diseases Society of America. Clin Infect Dis 2010; 50:133.
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