Angiotensin II

Q: Which of the inotrope has a withdrawal of neurohormonal vasoconstrictor mechanisms such as angiotensin II and norepinephrine?    (select one)

A) milrinone 
B)) dobutamine 


Answer: B

Dobutamine and digoxin increase the cardiac output by the withdrawal of neurohormonal vasoconstrictor mechanisms such as angiotensin II and norepinephrine. In other words, they negate each other's effects. The objective of the above question is to bring to the attention its uses with Angiotensin II agonists. Angiotensin II infusions are now widely used in ICUs for different kinds of shocks. Drug interactions should be considered prior to combine the therapies in cardiogenic shock.


#hemodynamics


Recommended read:

Laurence W. Busse, Michael T. McCurdy, Osman Ali, Anna Hall, Huaizhen Chen & Marlies Ostermann The effect of angiotensin II on blood pressure in patients with circulatory shock: a structured review of the literature Critical Care volume 21, Article number: 324 (2017)