TRALI

Q: Patients who develop transfusion-related acute lung injury (TRALI) with pre-existent acute respiratory distress syndrome (ARDS) have? (select one) 

 A) TRALI type I 
 B) TRALI type II


Answer: B

The objective of the above question is to bring to attention the new modification to the pre-existent classification of TRALI. This modification to/and the previous standard classification was developed by the National Heart, Lung, and Blood Institute (NHLBI) working group and a Canadian Consensus Conference (CCC).

• If a patient develops TRALI without any concomitant risk factor for ARDS, it is called type-I 
• If a patient develops TRALI with any concomitant risk factor for ARDS or even have signs of existing ARDS is called type-II

Due to copyright reasons, we can't reproduce full tables here but all previous and new tables can be accessed via references below.

#pulmonary

#hematology

References:

1. Kleinman S, Caulfield T, Chan P, et al. Toward an understanding of transfusion-related acute lung injury: statement of a consensus panel. Transfusion 2004; 44:1774. 

2. Toy P, Popovsky MA, Abraham E, et al. Transfusion-related acute lung injury: definition and review. Crit Care Med 2005; 33:721. 

3. Toy P, Kleinman SH, Looney MR. Proposed revised nomenclature for transfusion-related acute lung injury. Transfusion 2017; 57:709. Vlaar APJ, 

4. Toy P, Fung M, et al. A consensus redefinition of transfusion-related acute lung injury. Transfusion 2019; 59:2465.