Q: What is the dose of propofol in postoperative nausea and vomiting (PONV)?
Answer: Propofol can be successfully used as off-label in PONV. The recommended dose is 15 to 20 mg one time. It can be repeated under strict supervision due to the potential of respiratory depression, particularly in post-op patients. A similar dose has also been used with success in chemotherapy-induced resistant N&V.
This also reduces the morphine-induced pruritus, an added advantage in such scenarios.
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References:
1. Chatterjee S, Rudra A, Sengupta S. Current concepts in the management of postoperative nausea and vomiting. Anesthesiol Res Pract. 2011;2011:748031.
2. Chua WY, Wan Mat WR, Md Nor N, Mohammad Yusof A, Masdar A, Abdul Rahman R. Comparing sub-hypnotic doses of propofol to prevent intrathecal morphine-induced pruritus in caesarean delivery. Anesth Analg. 2016;123(3s):p63.
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