carvedilol

Q: Carvedilol should be used with high caution in? (select one)

A) End Stage renal disease
B) End stage liver disease


Answer: B

Carvedilol gets metabolized via liver, and should be used with high caution in severe hepatic disease. Serum concentrations may accumulate up to seven folds higher than in normal patients. 

Renal patients can take carvedilol without much adjustment as it is neither renally secreted nor get cleared by hemodialysis.

#pharmacology
#cardiology


Reference:

Satish Maharaj, Karan Seegobin, Julio Perez-Downes, Belinda Bajric, Simone Chang & Pramod Reddy Severe carvedilol toxicity without overdose – caution in cirrhosis Clinical Hypertension volume 23, Article number: 25 (2017)