AKI - definitation

Q: How the Acute Kidney Injury (AKI) is "defined" by Kidney Disease: Improving Global Outcomes (KDIGO)?


Answer: 

 The proposed definition from KDIGO includes

• an increase in serum creatinine by ≥0.3 mg/dL  within 48 hours, or
• an increase to ≥1.5 times the presumed baseline value that is known or presumed to have occurred within the prior seven days, or
• a decrease in urine volume to  < 0.5 mL/kg/hour over six hours 

Reference section include all 3 major guidelines to define AKI including

1.  Kidney Disease: Improving Global Outcomes (KDIGO) 
2.  Acute Dialysis Quality Initiative (ADQI) - RIFLE criteria
3. Acute Kidney Injury Network (AKIN) criteria

#nephrology

References:

1. Kidney Disease: Improving Global Outcomes (KDIGO) Acute Kidney Injury Work Group. KDIGO Clinical Practice Guideline for Acute Kidney Injury. Kidney Int Suppl 2012; 2:1.

2. Bellomo R, Ronco C, Kellum JA, et al. Acute renal failure-definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group. Crit Care 2004; 8:B204. 

3. Mehta RL, Kellum JA, Shah SV, et al. Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury. Crit Care 2007; 11:R31.