rigors from conventional amphotericin B

Q: Q: Which drug can be used to overcome rigors caused by conventional amphotericin B administration?



Answer:  Meperidine 

Although, an old trick but Meperidine has still been used off-label with success for shivering in post-operative patients. Usually, an intravenous (IV) dose of 12.5 mg is sufficient. 

Similarly, it can be used to overcome shivering which is common with the conventional form of amphotericin B. It requires a little higher dose in this instance i.e. IV 25 to 50 mg. Ideally, the dose should not be repeated. It takes about 10-12 minutes to show action after administration. It is still an off-label use.

#pharmacology


Reference: 

Burks LC, Aisner J, Fortner CL, Wiernik PH. Meperidine for the treatment of shaking chills and fever. Arch Intern Med. 1980;140(4):483-484.