Answer: Octreotide though commonly used in variceal bleeding is also found to be of benefit in bleeding peptic ulcers. It has three major effects
- reducing splanchnic blood flow
- inhibiting gastric acid secretion, and
- possible gastric cytoprotective effects
It is usually used as a backup treatment where endoscopy is not feasible for the patient. It is also recommended as an adjunct treatment before endoscopy or failed endoscopy.
#gastroenterology
References:
1. Bloom SR, Mortimer CH, Thorner MO, et al. Inhibition of gastrin and gastric-acid secretion by growth-hormone release-inhibiting hormone. Lancet 1974; 2:1106.
2. Johansson C, Aly A. Stimulation of gastric mucus output by somatostatin in man. Eur J Clin Invest 1982; 12:37.
3. Imperiale TF, Birgisson S. Somatostatin or octreotide compared with H2 antagonists and placebo in the management of acute nonvariceal upper gastrointestinal hemorrhage: a meta-analysis. Ann Intern Med 1997; 127:1062.
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