Risks for TRALI

Q: Which organ transplant surgery is found to be a risk factor for Transfusion Related Acute Lung Injury (TRALI)?

A) Liver
B) Lung
C) Kidney
D) Heart

Answer: A

There is a long list of risk factors identified in multiple studies for TRALI. It includes liver transplantation, liver disease, alcohol abuse, mechanical ventilation as well as high peak airway pressure on a ventilator, smoking, positive fluid balance, emergent cardiac surgery, hematologic malignancy, massive transfusion, sepsis, high sickness scores, platelet or plasma-containing products, and female gender.

#hematology
#hepatology
#transplantation


References:

1. Gajic O, Rana R, Winters JL, et al. Transfusion-related acute lung injury in the critically ill: prospective nested case-control study. Am J Respir Crit Care Med 2007; 176:886. 

2. Toy P, Gajic O, Bacchetti P, et al. Transfusion-related acute lung injury: incidence and risk factors. Blood 2012; 119:1757. 

3. Menis M, Anderson SA, Forshee RA, et al. Transfusion-related acute lung injury and potential risk factors among the inpatient US elderly as recorded in Medicare claims data, during 2007 through 2011. Transfusion 2014; 54:2182. 

4. Toy P, Bacchetti P, Grimes B, et al. Recipient clinical risk factors predominate in possible transfusion-related acute lung injury. Transfusion 2015; 55:947.