Remdesivir in pregnancy

 Q: During COVID-19 treatment Remdesivir should be avoided in pregnancy? 

A) True 

B) False

Answer: B

Management in pregnancy is not much different than in any other patient with COVID-19, though extra caution is needed. So far experience in COVID-19 and with previous viruses in the past such as the Middle East respiratory syndrome (MERS), Ebola, and Marburg virus, remdesivir is found to be safe at any stage of pregnancy.

COVID-19 literature continues to evolve fast. Readers are advised to consult updated guidelines before making any clinical decision.

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#pharmacology

References:

1. Igbinosa I, Miller S, Bianco K, et al. Use of remdesivir for pregnant patients with severe novel coronavirus disease 2019. Am J Obstet Gynecol. 2020;223(5):768-770. doi:10.1016/j.ajog.2020.08.001 

2.  Sheahan TP, Sims AC, Graham RL, et al. Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses. Sci Transl Med 2017; 9. 

3. Mulangu S, Dodd LE, Davey RT Jr, et al. A Randomized, Controlled Trial of Ebola Virus Disease Therapeutics. N Engl J Med 2019; 381:2293. 

4. Burwick RM, Yawetz S, Stephenson KE, et al. Compassionate Use of Remdesivir in Pregnant Women with Severe Covid-19. Clin Infect Dis 2020.