Q: All of the following are components of DRESS syndrome EXCEPT?
A Fever
B) Eosinophilia
C) Monocytosis
D) Skin rash
E) Organ involvement
Answer: C
DRESS syndrome stands for drug reaction with eosinophilia and systemic symptoms (DRESS). Criteria to diagnose DRESS syndrome is mostly based on clinical and laboratory grounds. Score includes
- Fever
- Enlarged lymph nodes - at least two different body sites
- Eosinophilia
- Atypical lymphocytes
- Skin involvement
- Organ involvement
- Resolution takes more than 15 days
A value between -1 and 2 is assigned to each feature.
Score:
- less than 2: Excluded
- 2 to 3: Possible
- 4 to 5: Probable
- 6 or above: Definite
It also requires exclusion of other causes such as HAV, HBV, HCV, mycoplasma, chlamydia, ANA, and negative blood cultures.
#pharmacology
References:
2. Kardaun SH, Sekula P, Valeyrie-Allanore L, et al. Drug reaction with eosinophilia and systemic symptoms (DRESS): an original multisystem adverse drug reaction. Results from the prospective RegiSCAR study. Br J Dermatol 2013; 169:1071.
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