seizure in meningitis

 Q: 32 years old male is admitted to ICU with seizure due to bacterial meningitis. Seizure in meningitis is a poor prognostic sign.

A) True

B) False

Answer: A

The occurrence of seizure during acute meningitis is usually a poor prognostic sign, particularly in adults. It is associated with a higher risk of neurologic deficits at hospital discharge and death. It is more common with pneumococcal meningitis. 

Also, these patients carry a higher risk of seizure subsequently later in life.

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References:

1. Zoons E, Weisfelt M, de Gans J, et al. Seizures in adults with bacterial meningitis. Neurology 2008; 70:2109. 

2. Annegers JF, Hauser WA, Beghi E, et al. The risk of unprovoked seizures after encephalitis and meningitis. Neurology 1988; 38:1407.

3. van de Beek D, de Gans J, Spanjaard L, et al. Clinical features and prognostic factors in adults with bacterial meningitis. N Engl J Med 2004; 351:1849.