Q: Which of the streptococcus bovis (S.Bovis) biotype is associated with increased risk of colonic neoplasia and infective endocarditis (IE)? (select one)
A) biotype I
B) biotype II
Answer: A
Although not fully explained but the most probable reason for this association is the presence of proteins in S. bovis biotype I that bind to overexpressed ligands in colonic neoplasms. This association is independent and have an extremely high odds ratio [OR] of 5.7. Patients who develop S. bovis IE are likely to have colonic neoplasia.
Less known fact is that similar association has been described with other gastrointestinal tract diseases such as gastric carcinoma, polyps, lymphoma, and colitis.
#oncology
#cardiology
#GI
References:
1. Boleij A, van Gelder MM, Swinkels DW, Tjalsma H. Clinical Importance of Streptococcus gallolyticus infection among colorectal cancer patients: systematic review and meta-analysis. Clin Infect Dis 2011; 53:870.
2. Corredoira-Sánchez J, García-Garrote F, Rabuñal R, et al. Association between bacteremia due to Streptococcus gallolyticus subsp. gallolyticus (Streptococcus bovis I) and colorectal neoplasia: a case-control study. Clin Infect Dis 2012; 55:491.
3. Ballet M, Gevigney G, Garé JP, et al. Infective endocarditis due to Streptococcus bovis. A report of 53 cases. Eur Heart J 1995; 16:1975.
4. Corredoira JC, Alonso MP, García-País MJ, et al. Is colonoscopy necessary in cases of infection by Streptococcus bovis biotype II? Eur J Clin Microbiol Infect Dis 2014; 33:171.
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