steroids in transplant surgery

Q: Methylprednisolone is usually given intraoperatively during lung transplantation. It should be given? (select one)

A) before the perfusion of graft

B) after the perfusion of graft

Answer: A

Immunosuppression is the most vital component in the success of transplantation. Some immunosuppressants are given preoperatively and some are perioperatively and are continued later on for a longer period of time for years. 

500 to 1000 mg of methylprednisolone is given in OR and preferably should be given before the perfusion of the graft. 

#transplantation

References:

1. Chandrashekaran S, Crow Pharm SA, Shah SZ, Arendt Pharm CJ, Kennedy CC. Immunosuppression for Lung Transplantation: Current and Future. Curr Transplant Rep. 2018 Sep;5(3):212-219. doi: 10.1007/s40472-018-0199-4. Epub 2018 Jul 13. PMID: 30740294; PMCID: PMC6366648.

2. Nelson J, Kincaide E, Schulte J, Hall R, Levine DJ. Immunosuppression in Lung Transplantation. Handb Exp Pharmacol. 2021 Nov 19. doi: 10.1007/164_2021_548. Epub ahead of print. PMID: 34796380.