Q: Multiple myeloma may lead to? (select one)
A) hyperphosphatemia
B) hypophosphatemia
Answer: B
In adult patients, multiple myeloma (MM) leads to Fanconi syndrome, which is characterized by impairment in proximal tubular function leading to urinary wasting of compounds normally reabsorbed in the proximal tubule. Overall result is hypophosphatemia, glucosuria, hypouricemia, aminoaciduria, and proximal renal tubular acidosis RTA-2) due to bicarbonate loss in the urine.
Beside MM, tenofovir is another major cause of Fanconi syndrome in adults.
#electrolytes
References:
Caras JA. Spurious hypophosphatemia associated with multiple myeloma. Endocr Pract. 1997 May-Jun;3(3):135-6. doi: 10.4158/EP.3.3.135. PMID: 15251473.
Jeffs P, Mangual-García M, González-Bóssolo A, Rivera-Santana N. Transient Hypophosphatemia: A Dangerous Event in Multiple Myeloma. Case Rep Endocrinol. 2021 Jan 16;2021:3609346. doi: 10.1155/2021/3609346. PMID: 33510918; PMCID: PMC7826227.
No comments:
Post a Comment