most nephrotoxic aminoglycoside

Q; Which of the following is considered the most nephrotoxic aminoglycoside? (select one)

A) Gentamicin 

B) Tobramycin

C) Amikacin

D) Netilmicin

E) Streptomycin 

Answer: A

Aminoglycosides are well known for their nephrotoxicity and ototoxicity. It is imperative to pick the least toxic aminoglycoside in conjunction with organism and reported sensitivity. In descending order, aminoglycosides in terms of nephrotoxicity are gentamicin, tobramycin, amikacin, netilmicin, and streptomycin.

Other effective strategy to counter toxicity is correcting hypovolemia, hypokalemia and hypomagnesemia before infusing aminoglycoside.

#pharmacology

References:

1. Humes HD. Aminoglycoside nephrotoxicity. Kidney Int 1988; 33:900.

2. Wargo KA, Edwards JD. Aminoglycoside-induced nephrotoxicity. J Pharm Pract. 2014 Dec;27(6):573-7. doi: 10.1177/0897190014546836. Epub 2014 Sep 7. PMID: 25199523.

3. Lopez-Novoa JM, Quiros Y, Vicente L, Morales AI, Lopez-Hernandez FJ. New insights into the mechanism of aminoglycoside nephrotoxicity: an integrative point of view. Kidney Int. 2011 Jan;79(1):33-45. doi: 10.1038/ki.2010.337. Epub 2010 Sep 22. PMID: 20861826.