clubbing in IPF

Q: Clubbing in Interstitial Lung disease (ILD) is __________  manifestation? (select one)

A) early

B) late

Answer: B

Clinical history and physical exam plays an integral role in differential diagnosis of ILD, like clubbing is common in idiopathic pulmonary fibrosis (IPF) and asbestosis) but rare in sarcoidosis and hypersensitivity pneumonitis. If present in ILD, it suggests advanced pulmonary fibrosis.

Clubbing is also a feature of cystic fibrosis, pulmonary arteriovenous malformations, cyanotic heart disease, malignancies of the lung and pleura, and inflammatory bowel disease.

#physical-exam

#pulmonary

Reference:

van Manen MJG, Vermeer LC, Moor CC, Vrijenhoeff R, Grutters JC, Veltkamp M, Wijsenbeek MS. Clubbing in patients with fibrotic interstitial lung diseases. Respir Med. 2017 Nov;132:226-231. doi: 10.1016/j.rmed.2017.10.021. Epub 2017 Nov 2. PMID: 29229102.