Case: 28 years old female with renal insufficiency is admitted to ICU with severe preeclampsia. Patient can receive the usual loading dose of Magnesium?
A) True
B) False
Answer: A
Although magnesium is renally excreted, the bolus dose can stay the same in preeclampsic patients with kidney disorder. This is since the volume of its distribution is not altered. After the bolus dose, the maintenance dose should be reduced and adjusted per level. The levels should be checked every one to two hours. Also, clinical signs should be regularly monitored to check for the continuous presence of patellar reflex.
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Reference:
Gestational Hypertension and Preeclampsia: ACOG Practice Bulletin, Number 222. Obstet Gynecol 2020; 135:e237.
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