Wednesday, September 28, 2022

Acute vs chronic GVHD

Q: Acute graft-versus-host disease (GVHD) uses a cutoff point if occurs within? (select one)

A) 48 hours
B) one week
C) 30 days
D) 100 days


Answer: D

GVHD is a multisystem complication status post allogeneic hematopoietic cell transplant (HCT). GVHD is usually marked by maculopapular rash, persistent nausea with or without vomiting, abdominal cramps, diarrhea, and hyperbilirubinemia. GVHD occurs when immune cells from donor (graft) recognize the recipient (host) as foreign. 

Classically, GVHD is divided into acute and chronic types. It is based on a cutoff of 100 days. Said that there are controversies around this conventional classification. Many experts use the nature of clinical signs and symptoms to differentiate between two variants.

#hematology
#oncology
#transplantation


References:

1. Toubai T, Sun Y, Reddy P. GVHD pathophysiology: is acute different from chronic? Best Pract Res Clin Haematol. 2008 Jun;21(2):101-17. doi: 10.1016/j.beha.2008.02.005. PMID: 18503979.

2. Filipovich AH, Weisdorf D, Pavletic S, et al. National Institutes of Health consensus development project on criteria for clinical trials in chronic graft-versus-host disease: I. Diagnosis and staging working group report. Biol Blood Marrow Transplant 2005; 11:945.

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