Q; 58 years old male with previous history of tumor lysis syndrome, which was successfully treated with Rasburicase a few months ago, is in relapse. Re-dose with Rasburicase is prescribed again. Which one precaution should be exercised?
Answer: Treatment for anaphylaxis at the bedside.
One of the rare but dreaded side effects of Rasburicase is anaphylaxis. The risk goes substantially high with repeated dose(s). This risk stays high even if the dose is repeated months after the first dose.
#pharmacology
#oncology
Reference:
Allen KC, Champlain AH, Cotliar JA, et al. Risk of anaphylaxis with repeated courses of rasburicase: a Research on Adverse Drug Events and Reports (RADAR) project. Drug Saf 2015; 38:183.
No comments:
Post a Comment