Stored platelets

Q: Platelet should be stored at? (select one)

A) room temperature

B) cold temperature

Answer: A

Platelets should be stored at room temperature. If stored in cold, von Willebrand factor (WVF) receptors will cluster on platelet surfaces. Also, it changes the morphology of platelets, which leads to the increased destruction by the hepatic macrophages. Saving bags should allow oxygen and carbon dioxide gas exchange. Addition of citrate prevents clotting and maintain proper PH. Dextrose provides the energy source.

The shelf-life of stored platelets is about five days but there are FDA approved containers available for storage up to a week.

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References:

1. McCullough J. Overview of platelet transfusion. Semin Hematol 2010; 47:235.

2. Hoffmeister KM, Felbinger TW, Falet H, et al. The clearance mechanism of chilled blood platelets. Cell 2003; 112:87.