Types of amyloidosis

Q: Which amyloidosis occurs due to recurring inflammation in the body? (select one)

A) AL amyloid 

B) ATTR amyloid 

C) AA amyloidosis

D) Insulin amyloid

Answer: C

There are various 18 different types of systemic and 22 localized forms of amyloidosis. Immunoglobulin light chain (AL) and transthyretin (ATTR) are primary amyloidoses.

AL amyloid is caused by plasma cell dyscrasia (choice A).

ATTR amyloid is usually hereditary or may be associated with aging. It is very common to cause cardiomyopathy (choice B).

AA amyloidosis is a potential complication of chronic diseases with ongoing or recurring inflammation resulting in a high serum amyloid A protein, an acute phase reactant (Choice C).

There are many types of amyloidosis, such as dialysis-related amyloidosis, heritable amyloidoses, organ-specific amyloid, and insulin amyloid (choice D).

#amyloidosis

Reference:

Benson MD, Buxbaum JN, Eisenberg DS, et al. Amyloid nomenclature 2020: update and recommendations by the International Society of Amyloidosis (ISA) nomenclature committee. Amyloid 2020; 27:217.