Q: What is the diagnostic criteria of Acute Chest Syndrome (ACS) in Sickle cell disease?
Answer: ACS is defined by a new pulmonary density on chest imaging involving at least one complete lung segment or diagnosis of Pneumonia, and at least one of the following:
- Temperature ≥38.5°C
- >3 percent decrease in SpO2 (oxygen saturation) from a documented steady-state value on room air
- Tachypnea (per age-adjusted normal)
- Intercostal retractions, nasal flaring, or use of accessory muscles of respiration
- Chest pain
- Cough
- Wheezing
- Rales
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Reference:
Ballas SK, Lieff S, Benjamin LJ, et al. Definitions of the phenotypic manifestations of sickle cell disease. Am J Hematol 2010; 85:6.
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