Uremic bleeding

Q: Out of the following, which treatment would NOT work in active bleeding from Uremia?

A) Desmopressin (DDAVP)

B) Hemodialysis

C) IV Estrogen

D) PO Estrogen

E) Cryoprecipitate

Answer:  B

Paradoxically, dialysis is very effective in preventing uremic bleeding but has no role in active bleeding from uremia. DDAVP is the most potent remedy in such situations, followed by cryoprecipitate. Estrogen (IV or PO) has also shown some effectiveness.

#nephrology

#hematology

Reference:

Hedges, S., Dehoney, S., Hooper, J. et al. Evidence-based treatment recommendations for uremic bleeding. Nat Rev Nephrol 3, 138–153 (2007). https://doi.org/10.1038/ncpneph0421