Adrenal insufficiency and Ca

Q: Adrenal insufficiency may cause? (select one)

A) Hypercalcemia 

B) Hypocalcemia 

Answer: A

Adrenal insufficiency causes hypercalcemia, particularly in the Addisonian crisis. This occurs due to various simultaneous processes, including increased bone resorption, volume contraction, proximal tubular calcium reabsorption, hemoconcentration, and calcium binding to serum proteins. It takes several days for correction after cortisol gets administrated.

#endocrinology

References:

1. Muls E, Bouillon R, Boelaert J, et al. Etiology of hypercalcemia in a patient with Addison's disease. Calcif Tissue Int 1982; 34:523.

2. Montoli A, Colussi G, Minetti L. Hypercalcaemia in Addison's disease: calciotropic hormone profile and bone histology. J Intern Med 1992; 232:535.