Q: 54 years old male with chronic psoriasis, and on cyclosporine presented with acute myocardial infarction, managed with percutaneous coronary intervention (PCI). The patient is prescribed a statin. The dose of statin should be kept? (select one)
A) higher
B) lower
Answer: B
Cyclosporine increases serum concentrations of all statins. This interaction may cause adverse effects, particularly myositis. The most notorious statins in this regard are lovastatin and simvastatin.
Pitavastatin, pravastatin, and rosuvastatin are less affected.
#pharmacology
#cardiology
Reference:
1. Wiggins BS, Saseen JJ, Page RL 2nd, et al. Recommendations for Management of Clinically Significant Drug-Drug Interactions With Statins and Select Agents Used in Patients With Cardiovascular Disease: A Scientific Statement From the American Heart Association. Circulation 2016; 134:e468.
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