Protamine risk

Q: Describe at least five sets of patient populations who are at high risk of protamine reaction?

Answer:

• Diabetics on NPH insulin,
• patients allergic to fish,
• pregnant and nursing women,
• previous protamine exposure, and
• men who have had vasectomies

#pharmacology

#hematology

References:

1. Brück S, Skrabal C, Träger K, Reinelt H. Kasuistik mit Literaturübersicht - Protamingabe bei Patientin mit Fischeiweißallergie [Risk factors for adverse reactions after protamine administration in adult patients undergoing cardiac surgery- a case report and literature review]. Anasthesiol Intensivmed Notfallmed Schmerzther. 2014 Jun;49(6):360-6. German. doi: 10.1055/s-0034-1383887. Epub 2014 Jul 8. PMID: 25004379.

2. Levy JH, Schwieger IM, Zaidan JR, Faraj BA, Weintraub WS. Evaluation of patients at risk for protamine reactions. J Thorac Cardiovasc Surg. 1989 Aug;98(2):200-4. PMID: 2755152.