EoE I-SEE

Q: 34 years old male is admitted to ICU with acute dysphagia due to food impaction in esophagus. GI service performed emergent endoscopy. Subsequent workup led to the diagnosis of eosinophilic esophagitis (EoE). The calculated Severity for Eosinophilic Esophagitis (I-SEE) score is reported as 15. Which of the following is NOT a part of I-SEE score? (select one)

A) Symptoms such as food impaction

B) Endoscopic features such as strictures

C) Eosinophilia in Complete Blood Count (CBC)

D) Histologic finding – Eosinophil burden

Answer: C

The following three clinical features are assigned a point value depending on findings

1. Symptoms and associated complications – Symptom frequency, food impaction, hospitalization

2. Endoscopic features – Edema, furrows, exudates, rings, strictures

3. Histology – Eosinophil burden per high power field

- 1 to 6 points = mild

- 7 to 14 points = moderate

- 15 points or higher = severe

I-SEE can be trend during subsequent visits.

Initially, eosinophilic esophagitis was abbreviated as "EE," but due to confusion with erosive esophagitis, now abbreviated as "EoE."

#GI

References:

1. Dellon ES, Khoury P, Muir AB, et al. A Clinical Severity Index for Eosinophilic Esophagitis: Development, Consensus, and Future Directions. Gastroenterology 2022; 163:59.

2. Cotton CC, Moist SE, McGee SJ, et al. A Newly Proposed Severity Index for Eosinophilic Esophagitis is Associated With Baseline Clinical Features and Successful Treatment Response. Clin Gastroenterol Hepatol 2023; 21:2534.