History of miscarriage and heart

Q: Female patients who have experienced spontaneous pregnancy loss have higher chances of having coronary heart disease (CHD)?

A) True

B) False

Answer: A

Female patients who experience spontaneous pregnancy loss (miscarriage or stillbirth) have high risk of Atherosclerotic Cardiovascular Disease (ASCVD) particularly coronary heart disease (CHD). The most probable explanation is their high level of procoagulant and proinflammatory state. Moreover, these patients also have higher risks of hypertension and diabetes.

#cardiology

#epidemiology

References:

1. Kharazmi E, Dossus L, Rohrmann S, Kaaks R. Pregnancy loss and risk of cardiovascular disease: a prospective population-based cohort study (EPIC-Heidelberg). Heart 2011; 97:49

2. Kharazmi E, Fallah M, Luoto R. Miscarriage and risk of cardiovascular disease. Acta Obstet Gynecol Scand 2010; 89:284.

3. Wagner MM, Bhattacharya S, Visser J, et al. Association between miscarriage and cardiovascular disease in a Scottish cohort. Heart 2015; 101:1954.

4. Grandi SM, Filion KB, Yoon S, et al. Cardiovascular Disease-Related Morbidity and Mortality in Women With a History of Pregnancy Complications. Circulation 2019; 139:1069.