CRD

Q: As per consensus-based guidelines from an academic panel (2004), 'death' is considered a grade in the management of chemotherapy-related diarrhea (CRD).

A) True

B) False

Answer: A

As per consensus-based guidelines from an academic panel convened to address the management of CRD in 2004, there were five grades of diarrhea.

Grade 1 - Increase of <4 stools per day over baseline; mild increase in ostomy output compared with baseline

Grade 2 - Increase of four to six stools per day over baseline; moderate increase in ostomy output compared with baseline; limiting instrumental activities of daily living (ADL).

Grade 3 - Increase of seven or more stools per day over baseline; hospitalization indicated; severe increase in ostomy output compared with baseline; limiting self-care ADL.

                         

Grade 4 - Life-threatening consequences; urgent intervention indicated

                         

Grade 5 - Death

                         

 It was advised to divide CRD into two categories          

•  "uncomplicated" (Grade 1 or 2)
•  "complicated." - all above grades                       

                         

  #GI

  #oncology

                         

  

                         

References:

                         

 1. Benson AB 3rd, Ajani JA, Catalano RB, et al. Recommended guidelines for the treatment of cancer treatment-induced diarrhea. J Clin Oncol 2004; 22:2918.

                         

2. National Institutes of Health, National Cancer Institute. Available at: https://ctep.cancer.gov/protocoldevelopment/electronic_applications/docs/CTCAE_v5_Quick_Reference_8.5x11.pdf (Accessed February 27, 2024).