Q: Which adjuvant treatment may take care of some of the central effects of Levetiracetam?
Answer: Vitamin B6 (Pyridoxin)
Levetiracetam (Keppra) may have central effects like depression, hallucinations, irritability, anger, suicidal thoughts, seizures, double vision, etc. Pyridoxine (vitamin B6) may curtail some of the central symptoms. These side effects can be particularly pronounced in the elderly population.
#neurology
#pharmacology
References:
1. Dreischmeier E, Zuloaga A, Kotloski RJ, Karasov AO, Gidal BE. Levetiracetam-associated irritability and potential role of vitamin B6 use in veterans with epilepsy. Epilepsy Behav Rep. 2021 May 3;16:100452. doi: 10.1016/j.ebr.2021.100452. PMID: 34142077; PMCID: PMC8188361.
2. Besag FMC, Vasey MJ, Sen A. Current evidence for adjunct pyridoxine (vitamin B6) for the treatment of behavioral adverse effects associated with levetiracetam: A systematic review. Epilepsy Behav. 2023 Mar;140:109065. doi: 10.1016/j.yebeh.2022.109065. Epub 2023 Feb 13. PMID: 36791631.
No comments:
Post a Comment