Properties of Librium

Q: Chlordiazepoxide (Librium) is a commonly used drug in ICU. Describe its four essential properties?

Answer: Chlordiazepoxide is unique in a sense and a good choice in alcohol withdrawal not only because its active metabolite has a very long half-life but also because it is

• amnestic,
• anxiolytic,
• hypnotic and
• skeletal muscle relaxant

#pharmacology

#toxicity

References:

1. Ahwazi HH, Patel P, Abdijadid S. Chlordiazepoxide. 2024 Jan 29. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. PMID: 31613439.

2. Kumar CN, Andrade C, Murthy P. A randomized, double-blind comparison of lorazepam and chlordiazepoxide in patients with uncomplicated alcohol withdrawal. J Stud Alcohol Drugs. 2009 May;70(3):467-74. doi: 10.15288/jsad.2009.70.467. PMID: 19371497.