Vitamin K

Q: Vitamin K1 is more effective than Vitamin K2.

A) True

B) False

Answer: B

There are two categories of Vitamin K.

Vitamin K1 is the most widely used form globally. It is a form produced by plants.

Vitamin K2 is mostly used in Japan. It is near human storage form as produced by bacteria and mitochondria. All other synthetic forms are also considered as Vitamin K2 for simplicity.

Both vitamin K1 and K2 are similarly effective in reversing coagulopathy.

#vitamins

References:

1. Nakagawa K, Hirota Y, Sawada N, et al. Identification of UBIAD1 as a novel human menaquinone-4 biosynthetic enzyme. Nature 2010; 468:117.

2. Ageno W, Gallus AS, Wittkowsky A, et al. Oral anticoagulant therapy: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest 2012; 141:e44S.

3. Hifumi T, Takada H, Ogawa D, et al. Vitamin K2 for the reversal of warfarin-related coagulopathy. Am J Emerg Med 2015; 33:1108.e1.