Q: What is dose dumping?
Answer: Dose dumping is a phenomenon of drug metabolism in which environmental factors causes the premature and mostly exaggerated release of a drug, causing particular drug toxicity. Most common reason of drug dumping is taking fatty meals with a particular drug that increases drug delivery. It is mostly described with extended-release forms of drug.
Various explanations have been given including breakdown of drug's capsule or stimulation of the body's absorptive surfaces to increase the drug uptake.
Alcohol is another major factor that may cause drug dumping syndrome.
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References:
1. Shader RI. Dose dumping and the dumping of doses. J Clin Psychopharmacol. 2007 Aug;27(4):327-8. doi: 10.1097/JCP.0b013e318133fc23. PMID: 17632214.
2. Bílik T, Pavelková M, Kubová K, Vysloužil J. Dose dumping of modified-release solid oral dosage forms. Ceska Slov Farm. 2022 Fall;71(6):251-258. English. PMID: 36513519.
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