Q: What is HOPE score?
Answer: The Hypothermia Outcome Prediction after ECLS (HOPE)
HOPE survival probability score is a survival probability score in percentage. It can be calculated online at www.hypothermiascore.org.
It is recommended that patients with a HOPE score of less than 10 percent should not be rewarmed.
Favorable prognostic factors at hospital admission in these patients are
- female sex
- mechanism other than asphyxiation (i.e., exposure or immersion rather than submersion or avalanche burial)
- Higher age*
- lower serum potassium concentration
- shorter duration of cardiopulmonary resuscitation (CPR)
- lower core temperature
Witnessed arrest and cardiac activity (ie, pulseless electrical activity or ventricular fibrillation rather than asystole) were associated with improved survival but were not included in the score.
*In the original HOPE cohort, the median age of survivors was 40 (range 18 to 56), while the median age of nonsurvivors was 29.5 (range 13 to 54).
HOPE score gets criticized due to its data from retrospective observational studies, methodologic limitations, selection bias and substantial overlap between groups for some parameters, such as age, duration of CPR (median 106 minutes for survivors and 120 minutes for nonsurvivors), and core temperature (median 23°C for survivors and 25°C for nonsurvivors).
Another registry is often used with the name HELP registry (reference # 4)
#hypothermia
References:
1. Pasquier M, Hugli O, Paal P, et al. Hypothermia outcome prediction after extracorporeal life support for hypothermic cardiac arrest patients: The HOPE score. Resuscitation 2018; 126:58.
2. Pasquier M, Rousson V, Darocha T, et al. Hypothermia outcome prediction after extracorporeal life support for hypothermic cardiac arrest patients: An external validation of the HOPE score. Resuscitation 2019; 139:321.
3. Rousson V, Hall N, Pasquier M. HOPE survival probability cutoff for ECLS rewarming in hypothermic cardiac arrest. Resusc Plus 2024; 18:100616.
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