Peds critical care

 Q: Which diuretic carries anti epileptic property particularly in neonates? 

 Answer: Bumex 

 Bumetanide (Bumex) is a loop diuretic. In the brain, bumetanide blocks the NKCC1 cation-chloride co-transporter, and thus decreases internal chloride concentration in neurons. In turn, this concentration change makes the action of GABA more hyperpolarizing, which may be useful for treatment of neonatal seizures, that quite often are not responsive to traditional GABA-targeted treatment, such as barbiturates. Bumetanide is currently under evaluation as a prospective antiepileptic drug. 


http://clinicaltrials.gov/ct2/show/NCT00830531