Q: In nephrogenic diabetes insipidus (DI), thiazide diuretics are frequently used, which despite a diuretic causes an overall fluid conservation. But it may frequently lead to hypokalemia. Addition of which other diuretic may help? 


Answer: Amiloride 

 Desmopressin does not work in nephrogenic DI. A thiazide diuretic or indomethacin may improve nephrogenic diabetes insipidus. Thiazide diuretics are sometimes combined with amiloride to prevent hypokalemia. Amiloride has potassium-sparing capacities which often actually results in mild hyperkalemia.