Q: What is the dose of Ketamine in RSI (Rapid Sequence Intubation)?

Answer: Ketamine is given intravenously - 1 to 2 mg/kg. In patients with severe shock, half or even one fourth of dose has been advocated by some.

It has a time to effect of 45 to 60 seconds, and a duration of action of 10 to 20 minutes.

Ketamine has all good properties for use in "awake intubation" or in "possible difficult intubation".  It preserves respiratory drive, has a quick onset of action, good hemodynamic profile and has an analgesic properties. 

The reemergence phenomenon (disturbing dreams) as patient emerges from ketamine-induced anesthesia, limits use of the drug for procedural sedation. Rreemergence phenomena can be decrease with concomitant use of a benzodiazepine