Q: How much water need to be mixed to prepare one vial of Dantrium?

Answer: 60 cc

Each vial of Dantrium Intravenous should be reconstituted by adding 60 mL of sterile water and the vial shaken until the solution is clear. 5% Dextrose or 0.9% Sodium Chloride are not compatible with Dantrium Intravenous.

Dantrium is used for the prophylaxis and treatment of Malignant Hyperthermia (MH). The recommended prophylactic dose of Dantrium Intravenous is 2.5 mg/kg, starting approximately 60-75 minutes before anticipated anesthesia. It requires infusion over approximately 1 hour.

In post crisis intravenous Dantrium is used to attenuate malignant hyperthermia. The i.v. dose of Dantrium in the postoperative period starts with 1 mg/kg or more as the clinical situation dictates.