Q: 48-year-old male after Orthotopic Heart Transplant (OHT) developed severe Disseminated intravascular coagulation (DIC). What should be most underlying worry?


Answer: Acute organ rejection

Though Disseminated intravascular coagulation (DIC) is a well-known phenomenon underlying various diseases in ICU and requires treatment of the underlying issue, but severe DIC immediately  after solid organ  transplantation should raise high suspicion of acute rejection and should alert physicians to take extra effort to salvage the transplant besides bleeding which is commonly fatal if not controlled.