Q: Out of  the following which antibiotic is found to be associated with eosinophilic pneumonia?

A) Linezolid
B) Daptomycin
C) Vancomycin
D) Erythromycin
E) Metronidazole



Answer:  B

 Daptomycin has been clearly shown to be associated with eosinophilic pneumonia, which can be life-threatening. To note, Daptomycin binds to pulmonary surfactant, and it is presumed that it accumulates in alveolar spaces and subsequently causes injury and the inflammation.



Reference: 

 Hayes D Jr, Anstead MI, Kuhn RJ. Eosinophilic pneumonia induced by daptomycin. J Infect 2007;54:e211-e213