Q: About  one-third of patients with Traumatic Brain Injury (TBI) develop possible life threatening coagulopathy. What is the mechanism of action behind it?


Answer: Acute TBI produces systemic release of tissue factor and brain phospholipids into the blood circulation leading to DIC and a consumptive coagulopathy.


Reference:

Zehtabchi S, Soghoian S, Liu Y, et al. The association of coagulopathy and traumatic brain injury in patients with isolated head injury. Resuscitation 2008; 76:52.