Q: Why Digoxin is not dialysable?
Answer: Digoxin has a unique property. It gets extensively bind to skeletal muscle and myocardium. It should be used with extreme caution once renal GFR is below 50 mL/minute. It should be used with the lowest possible dose of 0.0625 mg, once anywhere between 24 to 48 hours depending on the clinical effect and renal function.
Digoxin is not dialyzable in any form like hemodialysis, Continuous Ambulatory Peritoneal Dialysis (CAPD), or continuous renal replacement therapy (CRRT).
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Reference:
Golightly LK, Teitelbaum I, Kiser TH, et al, eds. Renal Pharmacotherapy: Dosage Adjustment of Medications Eliminated by the Kidneys. New York, NY: Springer Science; 2013.
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